Ootastic: PCOS in pictures

March 31, 2015

30 Film Females: Source Code (2011 again)

Filed under: 30 Film Females — ootastic @ 1:13 pm

As I mentioned in my recent summary of this blog series, 2011 seemed to have been a really good year for film females.  One of my favourites from this year is the brilliant Source Code, which I happened to re-watch (again!) on Film 4 recently and it prompted me to try something a bit different as described below. In this cerebral science fiction thriller, Jake Gyllenhall makes an engaging timey-wimey action hero but the film rests firmly on the humanity of love interest Michelle Monaghan and maternal instincts of US military captain Vera Farmiga.  These two women never meet, but they together they save the protagonist in every way a person can be saved (to quote Titanic).

I’m a fan of amusing gene names and was inspired by Scott Bakula’s voice cameo in the film to try searching for “Swiss cheese” in the UniProt database.  I found the aptly named Codanin-1 whose mutations cause a “spongy or Swiss-cheese appearance” in red blood cell precursors.  Of course, there’s an actual gene called “swiss cheese” in fruit flies whose mutations cause holes in the brain, but it’s got a boring functional name in humans.

I took the amino acid sequence for the main protein-coding section of Codanin-1 from the Ensembl genome browser (which has better formatting and, incidentally, is where my husband works) and found the hidden message highlighted in red (the other colours show unimportant genomic features, but I thought it looked pretty).  I couldn’t resist interpreting the phrase “Try Hard” as a spoof nod to the long-lived Bruce Willis action franchise, though instead of putative futuristic sequels (a la Jaws 19) I’d recommend watching Twelve Monkeys and Looper instead.  I’m sure this isn’t the only spurious phrase which can be discovered/constructed within an amino acid sequence (artificial examples include The Lost World and Craig Venter).  Why not see what you can find?

Codanin

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2 Comments »

  1. […] “Source Code” (2011 […]

    Pingback by 30 Film Females: Nearly Finished! | Ootastic: PCOS in pictures — October 25, 2015 @ 5:40 pm

  2. […] “Source Code” (2011 […]

    Pingback by 30 Film females: The Final Countdown | Ootastic: PCOS in pictures — September 29, 2016 @ 9:47 pm


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